An evolutionarily ancient transcription factor drives spore morphogenesis in mushroom-forming fungi

文献类型： 外文期刊

第一作者： Hou, Zhihao

作者： Hou, Zhihao;Merenyi, Zsolt;Csernetics, Arpad;Balint, Balazs;Hegedus, Botond;Foldi, Csenge;Wu, Hongli;Kristoffy, Zsolt;Abraham, Edit;Miklovics, Nikolett;Viragh, Mate;Liu, Xiao-Bin;Zsibrita, Nikolett;Lipinszki, Zoltan;Karcagi, Ildiko;Nagy, Laszlo G.;Hou, Zhihao;Foldi, Csenge;Yang, Yashu;Gao, Wei;Yang, Yashu;Gao, Wei;Zhang, Yan

作者机构：

期刊名称：CURRENT BIOLOGY （ 影响因子：7.5； 五年影响因子：9.3 ）

ISSN： 0960-9822

年卷期： 2025 年 35 卷 7 期

页码：

收录情况： SCI

摘要： Sporulation is the most widespread means of reproduction and dispersal in fungi and, at the same time, an industrially important trait in crop mushrooms. In the Basidiomycota, sexual spores are produced on specialized cells known as basidia, from which they are forcibly discharged with the highest known acceleration in nature. However, the genetics of sporulation remains poorly known. Here, we identify a new, highly conserved transcription factor, sporulation-related regulator 1 (srr1), and systematically address the genetics of spore formation for the first time in the Basidiomycota. We show that Srr1 regulates postmeiotic spore morphogenesis, but not other aspects of fruiting body development or meiosis, and its role is conserved in the phylogenetically distant, but industrially important, Pleurotus spp. (oyster mushrooms). We used RNA sequencing to understand genes directly or indirectly regulated by Srr1 and identified a strongly supported binding motif for the protein. Using an inferred network of putative target genes regulated by Srr1 and comparative genomics, we identified genes lost in secondarily non-ballistosporic taxa, including a novel sporulation-specific chitinase gene. Overall, our study offers systematic insights into the genetics of spore morphogenesis in the Basidiomycota.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序