文献类型： 外文期刊

第一作者： Zhang Nai-Xin

作者： Zhang Nai-Xin;Xu Cheng-Zhi;Qiao Chuan-Lin;Chen Hua-Lan;Wu Yun-Pu

作者机构：

关键词： influenza virus; viral protein; innate immunity; immune evasion

期刊名称：PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS （ 影响因子：0.282； 五年影响因子：0.289 ）

ISSN： 1000-3282

年卷期： 2022 年 49 卷 4 期

页码：

收录情况： SCI

摘要： Respiratory infection in humans and animals caused by influenza A viruses (IAV) is a severe economic and public health problem worldwide. Influenza virus will make the body's innate immune signal activated during the early infection, which plays the role of defending, clearing the virus, and assisting the adaptive immune response. However, the influenza virus has developed a variety of escape strategies in the process of co-evolution with the host that mainly blocks the host's innate immune pathway and inhibits the production of interferon and inflammatory factors through influenza virus self-proteins. We reviewed recent advances in host innate immune mechanisms against IAV infection and viral strategies for immune escaping, which may benefit the monitoring, target discovery, and vaccination development to prevent and control the influenza virus.

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