Development of an in silico serotyping database of Vibrio harveyi by identification and comparison of O-antigen encoding loci

文献类型： 外文期刊

第一作者： Guo, Genglin

作者： Guo, Genglin;Gao, Jinbo;Yang, Ze;Zhao, Chengxin;An, Jiahui

作者机构：

关键词： Vibrio harveyi; Lipopolysaccharide; Serotyping; Genome; cgMLST

期刊名称：AQUACULTURE （ 影响因子：3.9； 五年影响因子：4.1 ）

ISSN： 0044-8486

年卷期： 2024 年 593 卷

页码：

收录情况： SCI

摘要： Vibrio harveyi is an important pathogen for aquatic fish and invertebrates, that can lead to significant economic losses in the aquaculture industry. Rapid and accurate serotyping is essential for the diagnosis and epidemiological investigation of bacterial pathogens. In Vibrio spp., serotyping is based on lipopolysaccharide or capsule polysaccharide loci. In this study, we screened and extracted the location and full-length sequences of 12 different lipopolysaccharide biosynthesis loci from all available V. harveyi genome sequences from public database. Herein their gene composition, homology and variation are discussed, and a database is developed to rapidly type V. harveyi isolates based on differences in lipopolysaccharide loci. This study further analyzses the relationship between lipopolysaccharide loci and genome characteristics. The identification and characterization of these lipopolysaccharide loci could help researchers understand the genetic, molecular, and basis serotype structural specificity of this pathogen, and also provide opportunities for further development and improvement of the molecular serotyping method, which would aid the diagnosis and clinical treatment of the disease caused by this pathogen.

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