Fabrication and interaction mechanism of ovalbumin-based nanocarriers for metallic ion encapsulation

文献类型： 外文期刊

第一作者： Wan, Mengxi

作者： Wan, Mengxi;Huang, Zhenzhen;Yang, Xinxi;Chen, Qiqi;Chen, Leqi;Liang, Siyue;Zeng, Qingzhu;Su, Dongxiao;Zhang, Ruifen;Dong, Lihong

作者机构：

关键词： Hydrogen bond; hydrophobic interaction; mineral encapsulation; nanoparticle; ovalbumin

期刊名称：INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY （ 影响因子：3.612； 五年影响因子：3.575 ）

ISSN： 0950-5423

年卷期： 2022 年 57 卷 1 期

页码：

收录情况： SCI

摘要： Ovalbumin (OVA), due to its desirable physiochemistry properties and biocompatibility, has been widely adopted as bioactive compound carriers in the field of pharmacy and food. This study explored the interaction patterns between OVA and three flavonoids, namely naringin, hesperidin and anthocyanin, and the possibilities of OVA-flavonoid complexes as nanocarriers that entrap mineral substances. Results showed that ovalbumin interacts with three flavonoids through hydrophobic interaction and hydrogen bonding. The addition of flavonoids altered the secondary structure of OVA, decreasing the beta-sheets by 9-16% and increasing the random coils by about 20-60% for the hydroxyl groups of flavonoids coalesced with the C = O groups of amides of proteins by hydrogen bonding and hydrophobic interaction occurred from conjugation effects between aromatic rings of flavonoids and amino residues of OVA. The OVA-hesperidin complex showed comprehensive advantages over encapsulating mineral substances such as Mn, Fe, Cu and Zn.

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