Fu-Zheng-Xuan-Fei formula promotes macrophage polarization and Th17/ Treg cell homeostasis against the influenza B virus (Victoria strain) infection

文献类型： 外文期刊

第一作者： Xiao, Yan

作者： Xiao, Yan;Jin, Ningyi;Zhang, Jinxin;Li, Yiquan;Han, Jicheng;Xiao, Yan;Zhu, Xiangyu;Zhao, Wenxin;Jin, Ningyi;Lu, Huijun;Han, Jicheng

作者机构：

关键词： Influenza B virus; Antiviral drugs; Traditional Chinese medicines; Macrophage polarization; Th17; Treg homeostasis

期刊名称：JOURNAL OF ETHNOPHARMACOLOGY （ 影响因子：5.4； 五年影响因子：5.3 ）

ISSN： 0378-8741

年卷期： 2023 年 312 卷

页码：

收录情况： SCI

摘要： Ethnopharmacological relevance: Fu-Zheng-Xuan-Fei formula (FF) is a prescription that has been clinically used through the basic theory of traditional Chinese medicine (TCM) for treating viral pneumonia. Although FF possesses a prominent clinical therapeutic effect, seldom pharmacological studies have been reported on its antiinfluenza B virus (IBV) activity.Aim of the study: Influenza is an acute infectious respiratory disease caused by the influenza virus, which has high annual morbidity and mortality worldwide. With a global decline in the COVID-19 control, the infection rate of influenza virus is gradually increasing. Therefore, it is of great importance to develop novel drugs for the effective treatment of influenza virus. Apart from conventional antiviral drugs, TCM has been widely used in the clinical treatment of influenza in China. Therefore, studying the antiviral mechanism of TCM can facilitate the scientific development of TCM.Materials and methods: Madin-Darby canine kidney cells (MDCK) and BALB/c mice were infected with IBV, and FF was added to evaluate the anti-IBV effects of FF both in vitro and in vivo by Western blotting, immunofluorescence, flow cytometry, and pathological assessment. Results: It was found that FF exhibited anti-viral activity against IBV infection both in vivo and in vitro, while inducing macrophage activation and promoting M1 macrophage polarization. In addition, FF effectively regulated the signal transducer and activator of transcription (STAT) signaling pathway-mediated Th17/Treg balance to improve the lung tissue damage caused by IBV infection-induced inflammation. The findings provided the scientific basis for the antiviral mechanism of FF against IBV infection.Conclusions: This study shows that FF is a potentially effective antiviral drug against IBV infection.

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