Nobiletin inhibits hypoxia-induced placental redox imbalance and subsequent offspring brain damage by regulating the one-carbon metabolism

文献类型： 外文期刊

第一作者： Zhang, Meng-ling

作者： Zhang, Meng-ling;Yang, Qian;Bi, Zi-jun;Gao, Li-fang;Yu, Huan-ling;Zhang, Meng-ling;Li, Xiao-peng;Shan, Yang;Chen, Jia-hao

作者机构：

关键词： Nobiletin; Placenta; ROS; NADPH; One carbon metabolism

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）

ISSN： 1756-4646

年卷期： 2023 年 110 卷

页码：

收录情况： SCI

摘要： Nobiletin (NOB) is one of the major polymethoxyflavone in citrus peels, which has antioxidant activities. The purpose of this study was to investigate the effects of NOB on hypoxia-induced placental oxidative stress and its mechanism. In vitro experiments, JEG-3 hypoxic model was constructed, and treated with 100 mu M NOB. In vivo experiment, pregnant rats were injected intraperitoneally with 50 mg/kg body weight NOB daily, and the placental hypoxia model was established by RUPP. NOB hampered the reducing of reducing power in hypoxic cells, promoted NADPH to provide hydrogen donors to regenerate antioxidants GPX and GSH, thereby promoting the decomposition of ROS. NOB alleviated the adverse reaction of hypoxic placental one-carbon metabolism disorder by regulating the levels of homocysteine, DNMTs and TETs. Moreover, NOB suppressed offspring brain damage induced by RUPP. Taken together, NOB attenuated hypoxia-induced placental redox perturbation and subsequent offspring brain injury by modulating one-carbon metabolism.

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