Characterisation of extracellular vesicles properties and miRNAs profiles in Brown Swiss milk

文献类型： 外文期刊

第一作者： Du, Chunmei

作者： Du, Chunmei;Ma, Jian;Yin, Fuquan;Zhou, Guangxian;Wu, Jiang;Gan, Shangquan;Quan, Suyu;Xu, Mengsi;Lin, Liuxia;Gan, Shangquan

作者机构：

关键词： Brown Swiss milk; Extracellular vesicles; miRNAs; Immune response; Cell signal transduction

期刊名称：INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY （ 影响因子：4.4； 五年影响因子：3.5 ）

ISSN： 1364-727X

年卷期： 2024 年 77 卷 2 期

页码：

收录情况： SCI

摘要： The conserved extracellular vesicles (EVs)-miRNAs from milk might potentially influence human gene expression, or even introduce their analogous nucleotide chains into the human food chain. This study aimed to characterise the features of Brown Swiss milk EVs and the EVs-miRNAs profile. Brown Swiss milk EVs exhibited a cup-shaped morphology, with a distribution of (2.3 +/- 0.8) E + 11 particles/mL. Sequencing identified a total of 238 miRNAs, which were mainly implicated in immune response and cell signal transduction. The conservation of these milk EVs-miRNAs among species suggested they might be evolutionarily selected to regulate the growth and development of the newborns.

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