Edible plant extracellular vesicles: An emerging tool for bioactives delivery

文献类型： 外文期刊

第一作者： Fan, Shi-Jie

作者： Fan, Shi-Jie;Chen, Jia-Ying;Tang, Chao-Hua;Zhao, Qing-Yu;Zhang, Jun-Min;Qin, Yu-Chang;Fan, Shi-Jie;Chen, Jia-Ying;Tang, Chao-Hua;Zhao, Qing-Yu;Zhang, Jun-Min

作者机构：

关键词： edible plants; bioactives carriers; anti-inflammation; therapy; extracellular vesicles

期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：8.786； 五年影响因子：8.876 ）

ISSN： 1664-3224

年卷期： 2022 年 13 卷

页码：

收录情况： SCI

摘要： The extracellular vesicles (EVs) in edible food have a typical saucer-like structure and are nanoparticles released by numerous cells. They have different components and interact with other biological samples in diverse ways. Therefore, these nanoparticles could be used to develop bioactives delivery nanoplatforms and anti-inflammatory treatments to meet the stringent demands of current clinical challenges. This review aims to summarize current researches into EVs from edible plants, particularly those that can protect siRNAs or facilitate drug transportation. We will discuss their isolation, characterization and functions, their regulatory effects under various physiological and pathological conditions, and their immune regulation, anti-tumor, regeneration, and anti-inflammatory effects. We also review advances in their potential application as bioactives carriers, and medicinal and edible plants that change their EVs compositions during disease to achieve a therapy propose. It is expected that future research on plant-derived EVs will considerably expand their application.

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