An insecticide target in mechanoreceptor neurons

文献类型： 外文期刊

第一作者： Qiao, Xiaomu

作者： Qiao, Xiaomu;Zhang, Xiaoyu;Zhou, Zhendong;Guo, Lei;Wu, Weiping;Ma, Suhan;Huang, Jia;Zhang, Xinzhong;Montell, Craig;Montell, Craig

作者机构：

期刊名称：SCIENCE ADVANCES （ 影响因子：13.6； 五年影响因子：15.4 ）

ISSN： 2375-2548

年卷期： 2022 年 8 卷 47 期

页码：

收录情况： SCI

摘要： Hundreds of neurotoxic insecticides are currently in use. However, only a few direct targets have been identified. Here, using Drosophila and the insecticide flonicamid, we identified nicotinamidase (Naam) as a previous unidentified molecular target for an insecticide. Naam is expressed in chordotonal stretch-receptor neurons, and inhibition of Naam by a metabolite of flonicamid, TFNA-AM (4-trifluoromethylnicotinamide), induces accumulation of substrate nico-tinamide and greatly inhibits negative geotaxis. Engineered flies harboring a point mutation in the active site show insecticide resistance and defects in gravity sensing. Bees are resistant to flonicamid because of a gene duplication, resulting in the generation of a TFNA-AM-insensitive Naam. Our results, in combination with the absence of genes encoding Naam in vertebrate genomes, suggest that TFNA-AM and potential species-specific Naam inhibitors could be developed as novel insecticides, anthelmintics, and antimicrobials for agriculture and human health.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序