Transcriptome analysis reveals hepatotoxicity in zebrafish induced by cyhalofop-butyl

文献类型： 外文期刊

第一作者： Duan, Manman

作者： Duan, Manman;Guo, Xuanjun;Chen, Xiangguang;Guo, Mengyu;Zhang, Mengna;Xu, Hao;Wang, Chengju;Yang, Yang;Wang, Chengju;Yang, Yang

作者机构：

关键词： Cyhalofop-butyl; Zebrafish; Liver development; Hepatotoxic; RNA-Seq

期刊名称：AQUATIC TOXICOLOGY （ 影响因子：5.202； 五年影响因子：5.758 ）

ISSN： 0166-445X

年卷期： 2022 年 252 卷

页码：

收录情况： SCI

摘要： Cyhalofop-butyl is a highly effective aryloxyphenoxypropionate herbicide and widely used for weed control in paddy fields. With the increasing residue of cyhalofop-butyl, it poses a threat to the survival of aquatic organisms. Here, we investigated the effect of cyhalofop-butyl on zebrafish to explore its potential hepatotoxic mechanism. The results showed that cyhalofop-butyl induced hepatocyte degeneration, vacuolation and necrosis of larvae after embryonic exposure for 4 days and caused liver atrophy after 5 days. Meanwhile, the activities of enzymes related to liver function were significantly increased by 0.2 mg/L cyhalofop-butyl and higher, such as alanine transaminase (ALT) and aspartate transaminase (AST). And the contents of triglyceride (TG) involved in lipid metabolism were significantly decreased by 0.4 mg/L cyhalofop-buty. The expression of genes related to liver development was also significantly down-regulated. Furthermore, transcriptome results showed that the pathways involved in metabolism, immune system and endocrine system were significantly impacted, which may be related to hepatoxicity. To sum up, the present study demonstrated the hepatoxicity caused by cyhalofop-buty and its underlying mechanism. The results may provide new insights for the risk of cyhalofop-butyl to aquatic organisms and new horizons for the pathogenesis of hepatotoxicity.

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