Integrin A5B1-mediated endocytosis of polystyrene nanoplastics: Implications for human lung disease and therapeutic targets

文献类型： 外文期刊

第一作者： Qin, Wei

作者： Qin, Wei;Jiang, Qichen;Han, Mingming;Liang, Ji;Zhu, Chenxi;Khan, Nurzalina Abdul Karim;Abdullah, Anisah Lee Binti;Shau-Hwai, Aileen Tan;Zhou, Zihan;Tay, Yi Juin;Wang, Kai;Zhao, Yunlong;Li, Yi Ming;Jiang, Chunqi;Liao, Jiayuan;Si, Qin

作者机构：

关键词： Nano-plastics; Human lung diseases; ROS; Calcium channel

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：8.0； 五年影响因子：8.7 ）

ISSN： 0048-9697

年卷期： 2024 年 953 卷

页码：

收录情况： SCI

摘要： The extensive use of plastic products has exacerbated micro/nanoplastic (MPs/NPs) pollution in the atmosphere, increasing the incidence of respiratory diseases and lung cancer. This study investigates the uptake and cytotoxicity mechanisms of polystyrene (PS) NPs in human lung epithelial cells. Transcriptional analysis revealed significant changes in cell adhesion pathways following PS-NPs exposure. Integrin alpha 5 beta 1-mediated beta 1-mediated endocytosis was identified as a key promoter of PS-NPs entry into lung epithelial cells. Overexpression of integrin alpha 5 beta 1 enhanced PS-NPs internalization, exacerbating mitochondrial Ca2+ dysfunction and depolarization, which induced reactive oxygen species (ROS) production. Mitochondrial dysfunction triggered by PS-NPs led to oxidative damage, inflammation, DNA damage, and necrosis, contributing to lung diseases. This study elucidates the molecular mechanism by which integrin alpha 5 beta 1 facilitates PS-NPs internalization and enhances its cytotoxicity, offering new insights into potential therapeutic targets for microplastic-induced lung diseases.

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