Eco-Friendly Spiking Approach Based on Microfluidics for Preparation of Matrix Reference Materials

文献类型： 外文期刊

第一作者： Wang, Huijiao

作者： Wang, Huijiao;Wang, Huijiao;Liu, Huan;Sun, Huiwu;Zhang, Chaoying;Wang, Huijiao;Liu, Huan;Sun, Huiwu;Zhang, Chaoying

作者机构：

期刊名称：ACS OMEGA （ 影响因子：4.1； 五年影响因子：4.0 ）

ISSN： 2470-1343

年卷期： 2024 年 9 卷 19 期

页码：

收录情况： SCI

摘要： Medicated bath is the most common spiking method used in the development of matrix reference materials for aquatic products; however, the environmental issues caused by the treatment of waste liquid after medicated bath cannot be ignored. We proposed an environmentally friendly spiking method based on microfluidics, which significantly improved the drug utilization rate without the need for subsequent drug residue treatment. Finely processed minced fish samples were fully mixed with quinolone drugs, and minced fish gel microspheres were prepared by microfluidic technology, utilizing the gel's water-locking function to enhance the drug-loading capacity. The results showed that this method can significantly increase the drug-loading capacity of the matrix (2.33-4.03 times) compared with the traditional spiking methods. In addition, the matrix reference material prepared by this method has good stability, and the drug concentration was adjustable and controllable.

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