Single-cell RNA sequencing illuminates the ontogeny, conservation and diversification of cartilaginous and bony fish lymphocytes

文献类型： 外文期刊

第一作者： Wang, Hong-Yan

作者： Wang, Hong-Yan;Li, Yanan;Zhang, Xianghui;Liu, Xiang;Lu, Yifang;Li, Yubang;Huang, Yingyi;Li, Shuo;Zhang, Yangqing;Han, Shenglei;Jiang, Shuhong;Wang, Rui;Liu, Yuyan;Liu, Kaiqiang;Wang, Qian;Shao, Changwei;Wang, Hong-Yan;Li, Yanan;Zhang, Xianghui;Liu, Xiang;Lu, Yifang;Li, Yubang;Huang, Yingyi;Li, Shuo;Zhang, Yangqing;Han, Shenglei;Jiang, Shuhong;Wang, Rui;Liu, Yuyan;Liu, Kaiqiang;Wang, Qian;Shao, Changwei;Chen, Jian-Yang;He, Hang;Chen, Hongxi;Liu, Qun;Yang, Mingming;Zhang, Yingying;Zhou, Li;Tan, Fujian;Meng, Liang;Fan, Guangyi;Chen, Jian-Yang;He, Hang;Chen, Hongxi;Liu, Qun;Yang, Mingming;Zhang, Yingying;Zhou, Li;Tan, Fujian;Meng, Liang;Fan, Guangyi;Li, Yanan;Liu, Xiang;Jia, Zhao;Zou, Jun;Ji, Qianyue;Liu, Shanshan;Seim, Inge;Seim, Inge;Fan, Guangyi

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）

ISSN：

年卷期： 2024 年 15 卷 1 期

页码：

收录情况： SCI

摘要： Elucidating cellular architecture and cell-type evolution across species is central to understanding immune system function and susceptibility to disease. Adaptive immunity is a shared trait of the common ancestor of cartilaginous and bony fishes. However, evolutionary features of lymphocytes in these two jawed vertebrates remain unclear. Here, we present a single-cell RNA sequencing atlas of immune cells from cartilaginous (white-spotted bamboo shark) and bony (zebrafish and Chinese tongue sole) fishes. Cross-species comparisons show that the same cell types across different species exhibit similar transcriptional profiles. In the bamboo shark, we identify a phagocytic B cell population expressing several pattern recognition receptors, as well as a T cell sub-cluster co-expressing both T and B cell markers. In contrast to a division by function in the bony fishes, we show close linkage and poor functional specialization among lymphocytes in the cartilaginous fish. Our cross-species single-cell comparison presents a resource for uncovering the origin and evolution of the gnathostome immune system.

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