Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice
文献类型： 外文期刊
第一作者： Zhang, Yizi
作者： Zhang, Yizi;Peng, Xingjia;Xie, Yinzheng;Zheng, Xi;Zhang, Kun;Li, Dongli;Sun, Lingli;Lai, Xingfei;Wen, Shuai;Zhang, Zhenbiao;Li, Qiuhua;Chen, Ruohong;Sun, Shili;Li, Dongli
作者机构：
关键词： Inflammation; Oxidative stress; Gastrointestinal mucosal damage; Apoptosis
期刊名称：BIOMEDICINE & PHARMACOTHERAPY （ 影响因子：6.53； 五年影响因子：5.98 ）
ISSN： 0753-3322
年卷期： 2021 年 144 卷
页码：
收录情况： SCI
摘要： Jasminum grandiflorum L. is a medicinal plant used to treat hepatitis and gastritis, but the mechanisms underlying its protective effects against gastrointestinal mucosal damage remain to be elucidated. In this study, we analyzed the effects of four different extracts and two compounds from the flower of J. grandiflorum in a mouse model of HCl/EtOH-induced gastric ulcer. The flower extracts alleviated gastric mucosal ulceration by increasing PGE2 production and the activity of antioxidant enzymes, along with the suppression of reactive oxygen species (ROS) generation, lipid peroxidation, apoptosis-related proteins, pro-inflammatory cytokines and nitric oxide (NO) production.
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