Immunomodulatory activity of a water-soluble polysaccharide extracted from mussel on cyclophosphamide-induced immunosuppressive mice models

文献类型： 外文期刊

第一作者： Xiang, Xingwei

作者： Xiang, Xingwei;Wang, Rui;Chen, Yufeng;Liu, Shulai;Sun, Peilong;Xiang, Xingwei;Wang, Rui;Chen, Yufeng;Liu, Shulai;Sun, Peilong;Xiang, Xingwei;Wang, Rui;Chen, Yufeng;Liu, Shulai;Sun, Peilong;Xiang, Xingwei;Wang, Rui;Chen, Yufeng;Liu, Shulai;Sun, Peilong;Chen, Lin;Shen, Guoxin;Zheng, Bin;Deng, Shanggui

作者机构：

期刊名称：NPJ SCIENCE OF FOOD （ 影响因子：7.0； 五年影响因子：9.657 ）

ISSN：

年卷期： 2022 年 6 卷 1 期

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收录情况： SCI

摘要： This study aimed to investigate the protective effect of mussel polysaccharide (MP) on cyclophosphamide (Cy)-induced intestinal mucosal immunosuppression and microbial dysbiosis in mice. MP was shown to stimulate secretion of cytokines (SIgA, IL-2, IF-gamma, IL-4, IL-10) and production of transcription factors (occludin, claudin-1, ZO-1, mucin-2, IL-2, IF-gamma, IL-4, IL-10). Key proteins (p-I kappa B-alpha, p-p65) of the NF-kappa B pathway were upregulated after MP administration. SCFAs levels, which were decreased after the Cy treatment, were improved after treatment with MP. Furthermore, 16 S rRNA sequencing data of fecal samples revealed, through alpha-diversity and beta-diversity analysis, that MP improved microbial community diversity and modulate the overall composition of gut microbiota. Taxonomic composition analysis showed that MP increased the abundance of probiotics species (Lactobacillus) and decreased the proportion of pathogenic species (Desulfovibrio). These findings suggested that MP has a potential immunomodulatory activity on the immunosuppressive mice.

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