Mitochondrial prohibitin complex regulates fungal virulence via ATG24-assisted mitophagy

文献类型： 外文期刊

第一作者： Yan, Yaqin

作者： Yan, Yaqin;Yuan, Qinfeng;Liu, Caiyun;Chen, Xiaolin;Liu, Hao;Huang, Junbin;Zheng, Lu;Yan, Yaqin;Bao, Chonglai;Tang, Jintian;Hsiang, Tom

作者机构：

期刊名称：COMMUNICATIONS BIOLOGY （ 影响因子：6.548； 五年影响因子：6.816 ）

ISSN：

年卷期： 2022 年 5 卷 1 期

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收录情况： SCI

摘要： Prohibitins are highly conserved eukaryotic proteins in mitochondria that function in various cellular processes. The roles of prohibitins in fungal virulence and their regulatory mechanisms are still unknown. Here, we identified the prohibitins ChPhb1 and ChPhb2 in a plant pathogenic fungus Colletotrichum higginsianum and investigated their roles in the virulence of this anthracnose fungus attacking crucifers. We demonstrate that ChPhb1 and ChPhb2 are required for the proper functioning of mitochondria, mitophagy and virulence. ChPhb1 and ChPhb2 interact with the autophagy-related protein ChATG24 in mitochondria, and ChATG24 shares similar functions with these proteins in mitophagy and virulence, suggesting that ChATG24 is involved in prohibitin-dependent mitophagy. ChPhb1 and ChPhb2 modulate the translocation of ChATG24 into mitochondria during mitophagy. The role of ChATG24 in mitophagy is further confirmed to be conserved in plant pathogenic fungi. Our study presents that prohibitins regulate fungal virulence by mediating ATG24-assisted mitophagy. Prohibitins recruit ChATG24 into the mitochondria to modulate mitophagy, thereby affecting the virulence of Colletotrichum higginsianum.

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