Acidic polysaccharide from corn silk: Structural & conformational properties and hepatoprotective activity

文献类型： 外文期刊

第一作者： Zhang, Yi

作者： Zhang, Yi;Yao, Lianmou;Chen, Bingjie;Wang, Chunfang;Qiao, Yongjin;Liu, Yanfang;Gong, Kuijie;Wang, Feng

作者机构：

关键词： Corn silk; Acidic polysaccharide; Structural analysis; Conformational properties; HL-7702

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）

ISSN： 0141-8130

年卷期： 2023 年 236 卷

页码：

收录情况： SCI

摘要： This study aimed to investigate the structural characterization, conformational properties, and hepatoprotective activity of corn silk acidic polysaccharide (CSP-50E). CSP-50E with molecular weights of 1.93 x 105 g/mol was composed of Gal, Glc, Rha, Ara, Xyl, Man and uronic acid with a weight ratio of 12:25:1:2:2:5:21. Structural analysis with methylation indicated that CSP-50E mainly contained T-Manp, 4-substituted-D-Galp/GalpA, and 4substituted-D-Glcp. CSP-50E presented random coils conformation in an aqueous solution based on the analysis of HPSEC. In vitro experiments showed that CSP-50E exhibited significant hepatoprotective effects, CSP-50E reduce IL-6, TNF-alpha content, and AST, ALT activity to protect ethanol-induced damage liver cells (HL-7702), while the polysaccharide functioned mainly through the caspase cascade and mediate the mitochondrial apoptosis pathway. In this study, we describe a novel acidic polysaccharide from corn silk with hepatoprotective activity that facilitates the development and utilization of corn silk resources.

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