Mapping the regulatory genetic landscape of complex traits using a chicken advanced intercross line

文献类型： 外文期刊

第一作者： Zhu, Xiaoning

作者： Zhu, Xiaoning;Li, Chong;Ren, Jiangli;Song, Ran;Wang, Yuzhe;Hu, Xiaoxiang;Zhu, Xiaoning;Shu, Dingming;Qu, Hao;Zhu, Xiaoning;Bai, Zhonghao;Fang, Lingzhao;Luo, Chenglong;Shu, Dingming;Chen, Peng;Qu, Hao;Ren, Jiangli;Song, Ran;Wang, Yuzhe;Hu, Xiaoxiang;Wang, Yuzhe;Hu, Xiaoxiang

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）

ISSN：

年卷期： 2025 年 16 卷 1 期

页码：

收录情况： SCI

摘要： Complex traits exhibit a highly polygenic architecture that complicates gene mapping and molecular characterization. As a model organism for birds, chickens possess high-quality reference panels, functional annotations, and molecular quantitative trait locus maps. However, the genetic mechanisms underlying growth traits have not been systematically analyzed. Here, we develop a 16-generation advanced intercross line of chickens to enhance informative recombination and identify 154 single-gene quantitative trait loci. We use multiple co-localization methods to establish a network landscape of tissue-specific regulatory mutations and functional gene relationships. We leverage gene-clustering and restoration quantitative trait loci within the omnigenic model framework to elucidate the genetic regulation system of growth traits. Cross-species comparisons show the conserved functions of growth-related genes and divergent features of regulatory mechanisms in mammals and birds.

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