DEAD/DEAH-box helicase 5 is hijacked by an avian oncogenic herpesvirus to inhibit interferon beta production and promote viral replication

文献类型： 外文期刊

第一作者： Xu, Jian

作者： Xu, Jian;Cai, Yunhong;Jiang, Bo;Liu, Wenxiao;Cheng, Jing;Jin, Huan;Li, Yongqing;Ma, Zhenbang

作者机构：

关键词： Avian oncogenic herpesvirus; DEAD-box helicase 5; Interferon beta; Interferon regulatory factor 1; MDA5/TLR3 signaling

期刊名称：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY （ 影响因子：3.636； 五年影响因子：3.654 ）

ISSN： 0145-305X

年卷期： 2021 年 119 卷

页码：

收录情况： SCI

摘要： DEAD-box helicase 5 (DDX5) plays a significant role in tumorigenesis and regulates viral replication of several viruses. An avian oncogenic herpesvirus, Marek's disease virus (MDV), is widely known to cause immunosuppression and lymphoma in chickens. However, the underlying mechanisms of how DDX5 plays a role in viral replication remain unclear. In this study, we show that MDV inhibits the production of interferon beta (IFN-beta) in chicken embryo fibroblasts (CEFs) by increasing the expression level and promoting the nuclear aggregation of DDX5. We further reveal how DDX5 down-regulates melanoma differentiation-associated gene 5/toll-like receptor 3 signaling through the fundamental transcription factor, interferon regulatory factor 1. MDV replication is suppressed, and the production of IFN-beta is promoted in the DDX5 absented CEFs. Taken together, our investigations demonstrate that MDV inhibits IFN-beta production by targeting DDX5-mediated signaling to facilitate viral replication, which offers a novel insight into the mechanism by which an avian oncogenic herpesvirus replicates in chicken cells.

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