Characteristics of Chimeric West Nile Virus Based on the Japanese Encephalitis Virus SA14-14-2 Backbone
文献类型： 外文期刊
第一作者： Li, Guohua
作者： Li, Guohua;Li, Entao;Yan, Feihu;Zhang, Ying;Yi, Le;Chi, Hang;Sun, Weiyang;Wang, Tiecheng;Gao, Yuwei;Zhao, Yongkun;Yang, Songtao;Xia, Xianzhu;Li, Guohua;Xia, Xianzhu;Meng, Xianyong;Cui, Zhanding;Ren, Zhiguang;Liu, Jing;Li, Yuetao;Jin, Hongli;Cao, Zengguo;Huang, Pei;Wang, Hualei
作者机构：
关键词： Japanese encephalitis virus; West Nile virus; chimera
期刊名称：VIRUSES-BASEL （ 影响因子：5.048； 五年影响因子：5.127 ）
ISSN：
年卷期： 2021 年 13 卷 7 期
页码：
收录情况： SCI
摘要： West Nile virus disease (WND) is an arthropod-borne zoonosis responsible for nonspecific fever or severe encephalitis. The pathogen is West Nile virus belonging to the genus Flavivirus, family Flaviviridae. Every year, thousands of cases were reported, which poses significant public health risk. Here, we constructed a West Nile virus chimera, ChiVax-WN01, by replacing the prM Delta E gene of JEV SA14-14-2 with that of the West Nile virus NY99. The ChiVax-WN01 chimera showed clear, different characters compared with that of JEV SA14-14-2 and WNV NY99 strain. An animal study indicated that the ChiVax-WN01 chimera presented moderate safety and immunogenicity for 4-week female BALB/c mice.
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