Influence of hydroxypropylcyclodextrins on the toxicity of mixtures

文献类型： 外文期刊

第一作者： Lin, ZF

作者： Lin, ZF;Kong, DY;Zhong, P;Yin, KD;Dong, LH

作者机构：

关键词： hydroxypropylcyclodextrins (HPCDs);toxicity of mixtures;molecular structure;photobacterium phosphoreum

期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）

ISSN： 0045-6535

年卷期： 2005 年 58 卷 9 期

页码：

收录情况： SCI

摘要： We studied the influence of hydroxypropylcyclodextrins (HPCDs) on the toxicity of some mixtures. Using the Photobacterium phosphoreum toxicity test, the joint toxicological effect for Mixture I (containing p-nitrobenzaldehyde and 1-nitronaphthalene) and Mixture 11 (containing p-nitrobenzaldehyde and malononitrile) were determined in water and in aqueous solutions of HPCDs. The results indicate that, although the toxicological joint effect for Mixture I (simple addition) differs from that of Mixture 11 (synergism), alpha- and beta-HPCD can significantly reduce the toxicity of the test compounds, whereas gamma-HPCD has only a slight effect. Explanations for these observations are given that invoke the molecular structure of the individual chemicals as well as the structures of HPCDs. This provides information to assist the application of HPCDs in remediation of environmental pollution. (C) 2004 Elsevier Ltd. All rights reserved.

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