Alginate oligosaccharides ameliorate busulfan-induced renal tubule injury

文献类型： 外文期刊

第一作者： Yan, Xiaowei

作者： Yan, Xiaowei;Ma, Xiangping;Hao, Yanan;Fang, Hanhan;Lu, Dongxin;Shen, Wei;Ge, Wei;Zhao, Yong;Yan, Xiaowei;Ma, Xiangping;Hao, Yanan;Fang, Hanhan;Lu, Dongxin;Zhang, Hongfu;Zhao, Yong;Hao, Yanan;Zhang, Hongfu;Zhao, Yong;Liu, Jing

作者机构：

关键词： Alginate oligosaccharides (AOS); Kidney disease; Inflammation; Vasculature; Blood metabolites

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.223； 五年影响因子：5.178 ）

ISSN： 1756-4646

年卷期： 2022 年 92 卷

页码：

收录情况： SCI

摘要： Kidney diseases endanger human health and place a heavy burden on global health care systems. The current study aimed to explore the beneficial advances of alginate oligosaccharides (AOS) as a functional food on kidney structure and function, and the underlying mechanisms with a busulfan disrupted kidney model. We found that AOS improved the busulfan disrupted renal tubules. Busulfan increased the protein levels of kidney injury marker kidney injury molecule-1, apoptosis marker caspase 3 and inflammation marker TNF-alpha while they were recovered by AOS. On the other hand, AOS promoted the expression of proteins involved in vascular development alpha-SMA, CD34 and TGF-beta which were decreased by busulfan. Furthermore, AOS elevated the beneficial blood metabolites levels while reduced the harmful blood metabolites levels. Therefore, AOS can be applied to improve kidney function for the patients who take chemotherapeutics such as busulfan or other patients with chronic kidney diseases.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序