Engineering Gut Symbionts: A Way to Promote Bee Growth?

文献类型： 外文期刊

第一作者： Sattayawat, Pachara

作者： Sattayawat, Pachara;Inwongwan, Sahutchai;Noirungsee, Nuttapol;Disayathanoowat, Terd;Sattayawat, Pachara;Inwongwan, Sahutchai;Noirungsee, Nuttapol;Disayathanoowat, Terd;Li, Jilian;Guo, Jun

作者机构：

关键词： honeybee; gut symbionts; genetic engineering; digestion; detoxification

期刊名称：INSECTS （ 影响因子：3.0； 五年影响因子：3.1 ）

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年卷期： 2024 年 15 卷 5 期

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收录情况： SCI

摘要： Simple Summary Bees are important pollinators that play a role in balancing ecosystems; however, their survival rates have decreased due to many factors, including pathogens and exposure to pesticides. Bees have native mechanisms to help them tackle such challenges, and yet, these may not be enough. To this end, gut symbionts are beneficial, as they can help stimulate bees' immune systems and detoxify ingested toxic chemicals. To enhance the efficiency of these mechanisms, genetic engineering is proposed in this work to further optimize the ability of bee gut symbionts, particularly in the dominant bacteria Snodgrassella alvi and Gilliamella apicola. Engineering strategies are discussed according to the gut symbiotic bacteria's main roles in digestion, essential nutrient provision, and pesticide detoxification.Abstract Bees play a crucial role as pollinators, contributing significantly to ecosystems. However, the honeybee population faces challenges such as global warming, pesticide use, and pathogenic microorganisms. Promoting bee growth using several approaches is therefore crucial for maintaining their roles. To this end, the bacterial microbiota is well-known for its native role in supporting bee growth in several respects. Maximizing the capabilities of these microorganisms holds the theoretical potential to promote the growth of bees. Recent advancements have made it feasible to achieve this enhancement through the application of genetic engineering. In this review, we present the roles of gut symbionts in promoting bee growth and collectively summarize the engineering approaches that would be needed for future applications. Particularly, as the engineering of bee gut symbionts has not been advanced, the dominant gut symbiotic bacteria Snodgrassella alvi and Gilliamella apicola are the main focus of the paper, along with other dominant species. Moreover, we propose engineering strategies that will allow for the improvement in bee growth with listed gene targets for modification to further encourage the use of engineered gut symbionts to promote bee growth.

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