Antimicrobial activity and structure-activity relationships of molecules containing mono- or di- or oligosaccharides: An update

文献类型： 外文期刊

第一作者： Zhou, Tiantian

作者： Zhou, Tiantian;Ge, Yuewei;Zhou, Tiantian;Hao, Jiongkai;Tang, Qun;Ye, Wenchong;Fan, Chuangchuang;Wang, Xiaoyang;Wang, Chunmei;Zhang, Keyu;Han, Xiangan;Zhou, Wen;Hao, Jiongkai;Tang, Qun;Ye, Wenchong;Fan, Chuangchuang;Wang, Xiaoyang;Wang, Chunmei;Zhang, Keyu;Han, Xiangan;Chandarajoti, Kasemsiri;Chandarajoti, Kasemsiri

作者机构：

关键词： Anti-antibacterial activity; Mono or di-or oligosaccharides; Structure activity relationships (SAR); Antibacterial mechanisms

期刊名称：BIOORGANIC CHEMISTRY （ 影响因子：5.1； 五年影响因子：5.3 ）

ISSN： 0045-2068

年卷期： 2024 年 148 卷

页码：

收录情况： SCI

摘要： Bacterial infections are the second leading cause of death worldwide, and the evolution and widespread distribution of antibiotic -resistance elements in bacterial pathogens exacerbate the threat crisis. Carbohydrates participate in bacterial infection, drug resistance and the process of host immune regulation. Numerous antimicrobials derived from carbohydrates or contained carbohydrate scaffolds that are conducive to an increase in pathogenic bacteria targeting, the physicochemical properties and druggability profiles. In the paper, according to the type and number of sugar residues contained in antimicrobial molecules collected from the literatures ranging from 2014 to 2024, the antimicrobial activities, action mechanisms and structure -activity relationships were delineated and summarized, for purpose to provide the guiding template to select the type and size of sugars in the design of oligosaccharide-based antimicrobials to fight the looming antibiotic resistance crisis.

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