Immunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide

文献类型： 外文期刊

第一作者： Lin, Chenqiang

作者： Lin, Chenqiang;Zhang, Hui;Chen, Longjun;Fang, Yu;Chen, Jichen

作者机构：

关键词： immunomodulatory activity; Dictyophora echi-novolvata; spore polysaccharides

期刊名称：OPEN LIFE SCIENCES （ 影响因子：0.938； 五年影响因子：1.154 ）

ISSN： 2391-5412

年卷期： 2021 年 16 卷 1 期

页码：

收录情况： SCI

摘要： The purpose of this study was to investigate whether the Dictyophora echinovolvata spore polysaccharides (DESP) affect the immunity in immunocompromised mice induced by cyclophosphamide (CTX). The healthy female Kunming mice were randomly divided into six groups, including a normal control (NC) group, a positive control group, a model control (MC) group, and three groups treated with low-, intermediate-, and high dose polysaccharide, respectively. A series of immunoregulatory properties were determined, including humoral and cellular immunity, immune function, and immune factors of mononuclear macrophages. Compared with NC and MC groups, treatment with DESP significantly increased the spleen index and decreased the thymus index; increased the serum concentrations of immunoglobulin (Ig)A, IgG, IgM, hemolysin, IL-1 beta, and IL-2; delayed the allergic reaction; and improved the splenic lymphocyte transformation ability; and enhanced the phagocytosis of macrophages and the ability to secrete IL-6, TNF-alpha, caspase-1, and NO with DESP supplementation. These results indicated that DESP might have a good regulatory effect on CTX-induced immunodeficiency in mice, adjust the body's immune imbalance, and improve the symptoms of low immunity.

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