Formulation and Evaluation of Lipidized Imiquimod as an Effective Adjuvant

文献类型： 外文期刊

第一作者： Yin, Wenzhu

作者： Yin, Wenzhu;Deng, Bihua;Wang, Haiyan;Ma, Fang;Zhou, Mingxu;Lu, Yu;Zhang, Jinqiu;Xu, Zeyu;Lu, Yu;Zhang, Jinqiu

作者机构：

关键词： adjuvant; imiquimod; cholesterol; liposolubility; foot-and-mouth disease

期刊名称：ACS INFECTIOUS DISEASES （ 影响因子：5.3； 五年影响因子：5.1 ）

ISSN： 2373-8227

年卷期： 2023 年 9 卷 2 期

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收录情况： SCI

摘要： Adjuvants are essential for the induction of robust immune responses against vaccine antigens. Small-molecule TLR7 agonists hold high potential for this purpose. In this communication, imiquimod (IMQ) bearing a cholesterol lipid moiety derivative, IMQ-Chol, was designed and synthesized as a vaccine adjuvant, which could release parent IMQ molecules in aqueous conditions via amide bond hydrolysis. We performed a series of immunological evaluations by cooperating with the inactivated foot-and-mouth disease virus (FMDV). All of the results confirmed that IMQ-Chol could stimulate the body for a prolonged time to produce strong humoral and cellular immunity with a balanced Th1/Th2 immune response through a TLR7-related MAPK pathway. In addition, the results of the proof-of-concept vaccine indicated IMQ-Chol had a good effect on preventing and treating FMD in pigs.

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