文献类型： 外文期刊
第一作者： Liu, Le
作者： Liu, Le;Wang, Xiangwei;Mao, Ruoqing;Zhou, Yahua;Yin, Juanbin;Sun, Yuefeng;Yin, Xiangping
作者机构：
关键词： African swine fever virus; Live-attenuated vaccines; Safety; Protective immunity
期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.664 ）
ISSN： 0882-4010
年卷期： 2021 年 158 卷
页码：
收录情况： SCI
摘要： African swine fever (ASF) is an acute, hemorrhagic and severe infectious disease caused by African swine fever virus (ASFV) in domestic pigs and various wild boars, with a mortality rate up to 100%. ASF was first discovered in 1921 in Kenya. ASFV has a large genome and complex immune escape mechanism creating difficulties in the production of vaccines. Recently, remarkable advances have been made in vaccine development all over the world especially in live-attenuated vaccine. This article aims to review the research progress of ASF attenuated live vaccines in order to provide a reference for the development of vaccines for this disease.
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