文献类型： 外文期刊
第一作者： Deng, Hao
作者： Deng, Hao;Cao, Hongwei;Wang, Yanjin;Li, Jiaqi;Dai, Jingwen;Li, Lian-Feng;Qiu, Hua-Ji;Li, Su
作者机构：
关键词： viral replication organelles; viral helicase; DNA sliding clamp; viral DNA ligase; viral polymerase; antiviral drugs
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：4.0； 五年影响因子：5.1 ）
ISSN：
年卷期： 2024 年 15 卷
页码：
收录情况： SCI
摘要： Viral infections usually induce the rearrangement of cellular cytoskeletal proteins and organelle membrane structures, thus creating independent compartments [termed replication organelles (ROs)] to facilitate viral genome replication. Within the ROs, viral replicases, including polymerases, helicases, and ligases, play functional roles during viral replication. These viral replicases are pivotal in the virus life cycle, and numerous studies have demonstrated that the viral replicases could be the potential targets for drugs development. Here, we summarize primarily the key replicases within viral ROs and emphasize the advancements of antiviral drugs targeting crucial viral replicases, providing novel insights into the future development of antiviral strategies.
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