文献类型： 外文期刊
第一作者： Deng, Hao
作者： Deng, Hao;Cao, Hongwei;Wang, Yanjin;Li, Jiaqi;Dai, Jingwen;Li, Lian-Feng;Qiu, Hua-Ji;Li, Su
作者机构：
关键词： viral replication organelles; viral helicase; DNA sliding clamp; viral DNA ligase; viral polymerase; antiviral drugs
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：4.0； 五年影响因子：5.1 ）
ISSN：
年卷期： 2024 年 15 卷
页码：
收录情况： SCI
摘要： Viral infections usually induce the rearrangement of cellular cytoskeletal proteins and organelle membrane structures, thus creating independent compartments [termed replication organelles (ROs)] to facilitate viral genome replication. Within the ROs, viral replicases, including polymerases, helicases, and ligases, play functional roles during viral replication. These viral replicases are pivotal in the virus life cycle, and numerous studies have demonstrated that the viral replicases could be the potential targets for drugs development. Here, we summarize primarily the key replicases within viral ROs and emphasize the advancements of antiviral drugs targeting crucial viral replicases, providing novel insights into the future development of antiviral strategies.
分类号：
- 相关文献
作者其他论文 更多>>
-
A review of starch/polyvinyl alcohol (PVA) blend film: A potential replacement for traditional plastic-based food packaging film
作者：Deng, Hao;Su, Jiaqi;Zhang, Wanli;Khan, Ajahar;Rhim, Jong-Whan;Khan, Ajahar;Rhim, Jong-Whan;Sani, Mahmood Alizadeh;Goksen, Gulden;Kashyap, Piyush;Ezati, Parya
关键词：Biopolymer; Biodegradable; Food preservation; Coating
-
Investigating the Mechanism of Cadmium-Tolerant Bacterium Cellulosimicrobium and Ryegrass Combined Remediation of Cadmium-Contaminated Soil
作者：Li, Jiaqi;Xu, Xiaoyang;Song, Lanping;Na, Meng;Xu, Shangqi;Zhang, Jie;Huang, Yongjie;Zhou, Jihai;Li, Xiaoping;Zheng, Xianqing
关键词：Cd pollution; biological co-remediation; antioxidant enzyme system; none-enzymatic antioxidant system; microorganisms
-
Ferritin Nanoparticle Delivery of the E2 Protein of Classical Swine Fever Virus Completely Protects Pigs from Lethal Challenge
作者：Zhong, Dailang;Lu, Zhanhao;Xia, Yu;Wu, Hongxia;Zhang, Xinyu;Li, Mingzhi;Song, Xin;Wang, Yanjin;Moon, Assad;Qiu, Hua-Ji;Li, Yongfeng;Sun, Yuan;Xia, Yu;Li, Mingzhi;Sun, Yuan;Zhang, Xinyu
关键词：classical swine fever virus; E2 protein; ferritin; self-assembled nanoparticles; cell-mediated immune responses; neutralizing antibodies
-
Microbial contribution to 14 biogenic amines accumulation in refrigerated raw and deep-fried hairtails (Trichiurus lepturus)
作者：Deng, Hao;Wu, Guang;Guo, Li;Luo, Senlin;Yin, Qingchun;Deng, Hao;Zhou, Lingyu;Chen, Xiaomei;Yin, Qingchun;Deng, Hao;Luo, Senlin
关键词：UPLC -MS/MS; Biogenic amine; Hairtail; Bacterium; Storage
-
Characterization of Amino Acid Composition, Nutritional Value, and Taste of Fruits from Different Actinidia arguta Resources
作者：He, Yanli;Qin, Hongyan;Wen, Jinli;Cao, Weiyu;Fan, Shutian;Lu, Wenpeng;Li, Jiaqi;Li, Changyu;Wang, Lin
关键词：
-
Development of broad-spectrum immunoassay with monoclonal antibody to detect five eugenols and study of their molecular recognition mechanism
作者：Luo, Lin;Kang, Rui-Yao;He, Zhen-Xi;Chen, Zi-Jian;Xu, Zhen-Lin;Deng, Hao;Luo, Lin;Xu, Zhen-Lin;Chen, Zi-Jian;Jia, Bao-Zhu
关键词：Immunoassay; Hapten; Monoclonal antibody; Eugenol; Fish anesthetic
-
Development and application of an indirect ELISA for detection of antibodies against emerging atypical porcine pestivirus
作者：Song, Hao;Gao, Xiaowei;Li, Jing;Dong, Xinying;Fu, Yanhui;Shao, Lina;Zhang, Jiaoer;Qiu, Hua-Ji;Luo, Yuzi
关键词：Atypical porcine pestivirus; E2 protein; Indirect ELISA; Seroprevalence
