Enhancing the Antioxidant Activity by the Combination use of Resveratrol and Emodin

文献类型： 外文期刊

第一作者： Lu, Liushen

作者： Lu, Liushen;Qin, Ting;Chen, Kai;Xie, Jun;Pan, Liangkun;Xi, Bingwen;Xi, Bingwen

作者机构：

关键词： resveratrol; emodin; antioxidant; natural product

期刊名称：RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY （ 影响因子：1.1； 五年影响因子：1.0 ）

ISSN： 1068-1620

年卷期： 2024 年 50 卷 4 期

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收录情况： SCI

摘要： Objective: Resveratrol, a natural product found in plants, is a polyphenolic compound with strong antioxidant activity. In order to enhance the antioxidant activity of resveratrol, we have used a natural product emodin, which has multiple hydroxyl group structure similar to resveratrol. Methods: In this study, we investigated the antioxidant activities of resveratrol and emodin in vitro respectively, including their abilities to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals, hydroxyl radicals, and superoxide radicals. Results and Discussion: our results demonstrated that the combination of resveratrol and emodin significantly enhances antioxidant activity. And the process of their DPPH radical scavenging follows a first-order reaction kinetics equation. Finally, a possible mechanism for the scavenging of DPPH free radicals by resveratrol and emodin was proposed. Conclusions: We found that emodin combined with resveratrol can increase antioxidant activity. This study provides a new sight to enhance antioxidant activity.

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