Research on the mechanism of microwave-toughened starch on glucolipid metabolism in mice

文献类型： 外文期刊

第一作者： Li, Youdong

作者： Li, Youdong;Liu, Wei;Xu, Zhen-zhen;Zong, Ai-Zhen;Qiu, Bin;Jia, Min;Liu, Li-Na;Xu, Tong-Cheng;Li, Youdong;Liu, Wei;Xu, Zhen-zhen;Zong, Ai-Zhen;Qiu, Bin;Jia, Min;Liu, Li-Na;Xu, Tong-Cheng;Xiao, Jun-Xia

作者机构：

期刊名称：FOOD & FUNCTION （ 影响因子：5.396； 五年影响因子：5.534 ）

ISSN： 2042-6496

年卷期： 2020 年 11 卷 11 期

页码：

收录情况： SCI

摘要： Potato resistant starch (RS) was prepared by microwave-toughening treatment (MTT). This study investigated the beneficial effects of RS on high-fat diet (HFD)-induced hyperlipidemia in C57BL/6J mice by evaluating changes in the gut microbiota. The mice were fed low-fat diet with corn starch, HFD with corn starch, HFD with potato starch (HFP), or HFD with RS (HFR) for 6 weeks. The results showed that the HFR group had lower body weight and total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels compared with the HFP group. Moreover, the brown adipose tissue levels of uncoupling protein 1 (UCP-1), beta(3)-adrenoceptor (beta(3)-AR), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and PPAR-gamma coactivator-1 alpha (PGC-1 alpha) were increased. Our results showed that RS supplementation increased the Bacteroidetes/Firmicutes ratio and the abundance of short-chain fatty acid-producing Allobaculum, Ruminococcus, and Blautia. Our data suggest that RS prepared by MTT may be used as a prebiotic agent to prevent gut dysbiosis and obesity-related chronic diseases, such as hyperlipidemia, and obesity.

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