文献类型： 外文期刊
第一作者： Gu, Chaode
作者： Gu, Chaode;Huang, Zhiqiang;Wang, Hongwei;Gu, Chaode;Huang, Zhiqiang;Wang, Hongwei;Gu, Chaode;Sun, Yongyang;Shi, Shaowen;Li, Xiubo;Li, Nan;Liu, Yang;Guo, Zhendong;Jin, Ningyi;Zhao, Zongzheng;Li, Xiao;Sun, Yongyang;Shi, Shaowen;Li, Xiubo
作者机构：
关键词： monkeypox virus; HaCaT; TEM; characterization; RNA-seq
期刊名称：VIRUSES-BASEL （ 影响因子：3.5； 五年影响因子：3.7 ）
ISSN：
年卷期： 2024 年 16 卷 8 期
页码：
收录情况： SCI
摘要： Monkeypox virus (MPXV) can induce systemic skin lesions after infection. This research focused on studying MPXV proliferation and the response of keratinocytes. Using transmission electron microscopy (TEM), we visualized different stages of MPXV development in human immortalized keratinocytes (HaCaT). We identified exocytosis of enveloped viruses as the exit mechanism for MPXV in HaCaT cells. Infected keratinocytes showed submicroscopic changes, such as the formation of vesicle-like structures through the recombination of rough endoplasmic reticulum membranes and alterations in mitochondrial morphology. Transcriptome analysis revealed the suppressed genes related to interferon pathway activation and the reduced expression of antimicrobial peptides and chemokines, which may facilitate viral immune evasion. In addition, pathway enrichment analysis highlighted systemic lupus erythematosus pathway activation and the inhibition of the Toll-like receptor signaling and retinol metabolism pathways, providing insights into the mechanisms underlying MPXV-induced skin lesions. This study advances our understanding of MPXV's interaction with keratinocytes and the complex mechanisms leading to skin lesions.
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