Benzo-pyrrolidinyl substituted silicon phthalocyanines: A novel two-photon lysosomal nanoprobe for in vitro photodynamic therapy

文献类型： 外文期刊

第一作者： Chen, Xiuqin

作者： Chen, Xiuqin;Chen, Guizhi;Cao, Sitong;Ye, Ruoxin;Qiu, Ruoyi;Yang, Xiangyu;Peng, Yiru;Chen, Xiuqin;Sun, Hong

作者机构：

关键词： Pyrrolidine ketone; Phthalocyanine; Lysosomal targeting; Two-photon fluorescence imaging; Photodynamic therapy

期刊名称：PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY （ 影响因子：2.6； 五年影响因子：3.1 ）

ISSN： 1572-1000

年卷期： 2025 年 51 卷

页码：

收录情况： SCI

摘要： Lysosomes are pivotal in diverse physiological phenomena, encompassing autophagy, apoptosis, and cellular senescence. The demand for precise tumors treatment has led to the development of specific lysosome-targeting probes capable of elucidating lysosomal dynamics and facilitating targeted cell death. In this research, we report the synthesis and characterization of a novel benzopyrrolidinyl-substituted silicon phthalocyanine (Py-SiPc), designed for selective lysosome labeling and Fluorescence imaging-guided in vitro photodynamic therapy. Furthermore, we encapsulated Py-SiPc within a biocompatible nanocarrier, dipalmitoylphosphatidylethanolaminepolyethylene glycol 2000 (DSPE), to create water-soluble nanoparticles (DSPE@Py-SiPc). These nanoparticles exhibit exceptional lysosome labeling capabilities, as evidenced by bioimaging techniques. Upon exposure to laser irradiation, DSPE@Py-SiPc efficiently induces the production of reactive oxygen species, impairing lysosomal function and triggering lysosomal-mediated cell death. The DSPE@Py-SiPc system emerges as a promising photosensitizer.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序