Nicotinamide Efficiently Suppresses Porcine Epidemic Diarrhea Virus and Porcine Deltacoronavirus Replication

文献类型： 外文期刊

第一作者： Li, Mingxia

作者： Li, Mingxia;Zhang, Liping;Pan, Li;Zhou, Peng;Yu, Ruiming;Zhang, Zhongwang;Lv, Jianliang;Guo, Huichen;Wang, Yonglu;Liu, Xinsheng;Li, Mingxia;Xiao, Sa

作者机构：

关键词： nicotinamide; porcine epidemic diarrhea virus; porcine deltacoronavirus; replication

期刊名称：VIRUSES-BASEL （ 影响因子：4.7； 五年影响因子：4.8 ）

ISSN：

年卷期： 2023 年 15 卷 7 期

页码：

收录情况： SCI

摘要： Porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PDCoV), members of the genus Coronavirus, mainly cause acute diarrhea, vomiting and dehydration in piglets, and thus lead to serious economic losses. In this study, we investigated the effects of nicotinamide (NAM) on PEDV and PDCoV replication and found that NAM treatment significantly inhibited PEDV and PDCoV reproduction. Moreover, NAM plays an important role in replication processes. NAM primarily inhibited PEDV and PDCoV RNA and protein synthesis rather than other processes. Furthermore, we discovered that NAM treatment likely inhibits the replication of PEDV and PDCoV by downregulating the expression of transcription factors through activation of the ERK1/2/MAPK pathway. Overall, this study is the first to suggest that NAM might be not only an important antiviral factor for swine intestinal coronavirus, but also a potential candidate to be evaluated in the context of other human and animal coronaviruses.

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