Dietary supplements: clinical cholesterol-lowering efficacy and potential mechanisms of action

文献类型： 外文期刊

第一作者： Ge, Qian

作者： Ge, Qian;Yan, Yue;Zhao, Danqing;Zhang, Jing;Li, Caihong;Chen, Wang;Yang, Binkun;Chen, Xiang;Yi, Zicheng;Chang, Tengwen;Luo, Yang;Teng, Tai;Cao, Caixia

作者机构：

关键词： Dietary supplement; Cholesterol; Cholesterol-lowering; Hypocholesterolemic activity; Clinical trial

期刊名称：INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION （ 影响因子：3.9； 五年影响因子：4.1 ）

ISSN： 0963-7486

年卷期： 2024 年 75 卷 4 期

页码：

收录情况： SCI

摘要： This review aims to analyse the efficacy of dietary supplements in reducing plasma cholesterol levels. Focusing on evidence from meta-analyses of randomised controlled clinical trials, with an emphasis on potential mechanisms of action as supported by human, animal, and cell studies. Certain dietary supplements including phytosterols, berberine, viscous soluble dietary fibres, garlic supplements, soy protein, specific probiotic strains, and certain polyphenol extracts could significantly reduce plasma total and low-density lipoprotein (LDL) cholesterol levels by 3-25% in hypercholesterolemic patients depending on the type of supplement. They tended to be more effective in reducing plasma LDL cholesterol level in hypercholesterolemic individuals than in normocholesterolemic individuals. These supplements worked by various mechanisms, such as enhancing the excretion of bile acids, inhibiting the absorption of cholesterol in the intestines, increasing the expression of hepatic LDL receptors, suppressing the activity of enzymes involved in cholesterol synthesis, and activating the adenosine monophosphate-activated protein kinase signalling pathway.

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