Overcoming the High Error Rate of Composite DNA Letters-Based Digital Storage through Soft-Decision Decoding

文献类型： 外文期刊

第一作者： Xu, Yaping

作者： Xu, Yaping;Ding, Lulu;Wu, Shigang;Ruan, Jue;Ding, Lulu

作者机构：

关键词： composite DNA letter; DNA digital storage (DDS); error-correcting code (ECC); soft-decision decoding

期刊名称：ADVANCED SCIENCE （ 影响因子：14.3； 五年影响因子：16.3 ）

ISSN：

年卷期： 2024 年

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收录情况： SCI

摘要： Composite DNA letters, by merging all four DNA nucleotides in specified ratios, offer a pathway to substantially increase the logical density of DNA digital storage (DDS) systems. However, these letters are susceptible to nucleotide errors and sampling bias, leading to a high letter error rate, which complicates precise data retrieval and augments reading expenses. To address this, Derrick-cp is introduced as an innovative soft-decision decoding algorithm tailored for DDS utilizing composite letters. Derrick-cp capitalizes on the distinctive error sensitivities among letters to accurately predict and rectify letter errors, thus enhancing the error-correcting performance of Reed-Solomon codes beyond traditional hard-decision decoding limits. Through comparative analyses in the existing dataset and simulated experiments, Derrick-cp's superiority is validated, notably halving the sequencing depth requirement and slashing costs by up to 22% against conventional hard-decision strategies. This advancement signals Derrick-cp's significant role in elevating both the precision and cost-efficiency of composite letter-based DDS.

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