Chemical Components of Volatile Oil Extracted from the Fermentation Broth of Ganoderma lingzhi (Agaricomycetes) Coupled with Its Antitumor and Antioxidant Activities In Vitro

文献类型： 外文期刊

第一作者： Wang, Chan

作者： Wang, Chan;Liu, Wei;Wei, Yutian;Han, Wei;Wang, Chan;Liu, Wei;Wei, Yutian;Guo, Xiaoyu;Zhang, Jingsong;Tang, Chuanhong;Feng, Jie;Feng, Na;Wang, Chan;Liu, Wei;Wei, Yutian;Guo, Xiaoyu;Zhang, Jingsong;Tang, Chuanhong;Feng, Jie;Feng, Na;Wang, Chan;Liu, Wei;Wei, Yutian;Guo, Xiaoyu;Zhang, Jingsong;Tang, Chuanhong;Feng, Jie;Feng, Na;Wang, Chan;Liu, Wei;Wei, Yutian;Guo, Xiaoyu;Zhang, Jingsong;Tang, Chuanhong;Feng, Jie;Feng, Na;Guo, Xiaoyu;Feng, Na;Han, Wei

作者机构：

关键词： Ganoderma lingzhi; fermentation broth; volatile oil; antitumor activity; antioxidant activity; medicinal mushrooms

期刊名称：INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS （ 影响因子：1.2； 五年影响因子：1.4 ）

ISSN： 1521-9437

年卷期： 2023 年 25 卷 4 期

页码：

收录情况： SCI

摘要： Volatile oil extracted from fermentation broth of Ganoderma lingzhi by hydrodistillation was analyzed based on gas chromatography-mass spectrometry (GC-MS). Its antitumor activity was tested on K562, SW620, A549, HepG2 cells in vitro. In addition, the antioxidant activity of the oil was determined using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. In total, 16 constituents were identified accounting for about 99.99% of the total volatile oil in the fermentation broth of G. lingzhi. Among these components, 1-propanol (33.33%), phenylacetaldehyde (24.24%), 2-hexyl-1-decanol (12.12%) were found to be the major constituents. The antitumor results showed that the IC50 of the inhibition to the proliferation of K562, SW620, A549, HepG2 cells were 32.2, 78.9, 96.4, 99.0 mu g/mL, respectively. And the oil could inhibit the proliferation of K562 cells by apoptosis induction and cell cycle arrest at S phase. Moreover, the oil exhibited radical scavenging activity (IC50 = 0.1469 mg/mL) in DPPH assay.

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