Inhibitory Effects of the Natural Product Esculetin on Phytophthora capsici and Its Possible Mechanism

文献类型： 外文期刊

第一作者： Wang, Bi

作者： Wang, Bi;Li, Pirui;Xu, Shu;Feng, Xu;Zhao, Xingzeng;Chen, Yu;Liu, Lanying;Xu, Yannan

作者机构：

关键词： baseline sensitivity; botanical fungicide; esculetin; mode of action; Phytophthora capsici

期刊名称：PLANT DISEASE （ 影响因子：4.438； 五年影响因子：4.7 ）

ISSN： 0191-2917

年卷期： 2021 年 105 卷 6 期

页码：

收录情况： SCI

摘要： Esculetin is an important plant-derived natural product that has multiple bioactivities and applications. Phytophthora capsici is a notorious plant pathogen capable of infecting a broad range of hosts. In this study, we evaluated the antifungal activity of esculetin against P. capsici. The baseline sensitivity of P. capsici to esculetin was established using 108 isolates collected from various geographical regions in the Jiangsu and Shandong Provinces of China. The median effective concentration (EC50) values for esculetin ranged from 2.08 to 16.46 mu g/ml (mean, 6.87 +/- 2.70 mu g/ml) and were normally distributed. Furthermore, both zoospore production and germination were strongly inhibited by esculetin. Importantly, esculetin exhibited protective as well as curative activities against P. capsici on tomato and was capable of restricting the early infection of P. capsici on Nicotiana benthamiana. We found that the esculetin treatment led to cell membrane damage of P. capsici, as revealed by morphological observations and measurements of relative conductivity and malondialdehyde (MDA). Finally, our results also suggested that esculetin may adversely affect P. capsici by inhibiting its DNA and protein synthesis. These findings will contribute to the broader evaluation of the use of esculetin to control diseases caused by P. capsici and toward a better understanding of its mode of action as a potential fungicide.

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