Cross-Species Insights into Trophoblast Invasion During Placentation Governed by Immune-Featured Trophoblast Cells

文献类型： 外文期刊

第一作者： Zang, Xupeng

作者： Zang, Xupeng;Wang, Wenjing;Ding, Yue;Wang, Yongzhong;Gu, Shengchen;Shang, Yijun;Gan, Jianyu;Jiang, Lei;Xu, Zheng;Huang, Sixiu;Li, Zicong;Wu, Zhenfang;Gu, Ting;Cai, Gengyuan;Hong, Linjun;Zhang, Dan;Meng, Fanming;Shi, Junsong;Cai, Gengyuan;Xu, Zheng;Huang, Sixiu;Li, Zicong;Wu, Zhenfang;Gu, Ting;Cai, Gengyuan;Hong, Linjun

作者机构：

关键词： iTrophoblast; placentation; preeclampsia; trophoblast invasion

期刊名称：ADVANCED SCIENCE （ 影响因子：14.1； 五年影响因子：15.6 ）

ISSN：

年卷期： 2024 年 11 卷 42 期

页码：

收录情况： SCI

摘要： Proper development of the placenta, the transient support organ forms after embryo implantation, is essential for a successful pregnancy. However, the regulation of trophoblast invasion, which is most important during placentation, remains largely unknown. Here, rats, mice, and pigs are used as biomedical models, used scRNA-seq to comparatively elucidate the regulatory mechanism of placental trophoblast invasion, and verified it using a human preeclampsia disease model combined with scStereo-seq. A dual-featured type of immune-featured trophoblast (iTrophoblast) is unexpectedly discovered. Interestingly, iTrophoblast only exists in invasive placentas and regulates trophoblast invasion during placentation. In a normally developing placenta, iTrophoblast gradually transforms from an immature state into a functional mature state as it develops. Whereas in the developmentally abnormal preeclamptic placenta, disordered iTrophoblast transformation leads to the accumulation of immature iTrophoblasts, thereby disrupting trophoblast invasion and ultimately leading to the progression of preeclampsia. Through cross-species comparison, this study reveals the presence of a dual-featured type of immune-featured trophoblast (iTrophoblast) in invasive placentas, which regulates trophoblast invasion during placentation. Immature iTrophoblasts gradually transform into functional maturity with development, and their transformation disorder leads to the accumulation of immature iTrophoblasts, thereby disrupting trophoblast invasion and causing disease progression. image

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