The BAS chromatin remodeler determines activation and plant growth in Arabidopsis

文献类型： 外文期刊

第一作者： Zhu, Tao

作者： Zhu, Tao;Yu, Yaoguang;Zhu, Jiameng;Liang, Zhenwei;Song, Xin;Fu, Wei;Li, Chenlong;Wei, Chuangqi;Wang, Zhi-Yong;Wei, Chuangqi;Zhang, Zhenzhen;Zhang, Zhenzhen;Cui, Yuhai

作者机构：

期刊名称：DEVELOPMENTAL CELL （ 影响因子：11.8； 五年影响因子：12.4 ）

ISSN： 1534-5807

年卷期： 2024 年 59 卷 7 期

页码：

收录情况： SCI

摘要： Brassinosteroid (BR) signaling leads to the nuclear accumulation of the BRASSINAZOLE-RESISTANT 1 (BZR1) transcription factor, which plays dual roles in activating or repressing the expression of thousands of genes. BZR1 represses gene expression by recruiting histone deacetylases, but how it activates transcription of BR -induced genes remains unclear. Here, we show that BR reshapes the genome-wide chromatin accessibility landscape, increasing the accessibility of BR -induced genes and reducing the accessibility of BR -repressed genes in Arabidopsis. BZR1 physically interacts with the BRAHMA -associated SWI/SNF (BAS) -chromatin -remodeling complex on the genome and selectively recruits the BAS complex to BR -activated genes. Depletion of BAS abrogates the capacities of BZR1 to increase chromatin accessibility, activate gene expression, and promote cell elongation without affecting BZR1's ability to reduce chromatin accessibility and expression of BR -repressed genes. Together, these data identify that BZR1 recruits the BAS complex to open chromatin and to mediate BR -induced transcriptional activation of growth -promoting genes.

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