The design and engineering of synthetic genomes

文献类型： 外文期刊

第一作者： James, Joshua S.

作者： James, Joshua S.;Cai, Yizhi;James, Joshua S.;Chew, Wei Leong;Dai, Junbiao;Dai, Junbiao

作者机构：

期刊名称：NATURE REVIEWS GENETICS （ 影响因子：52.0； 五年影响因子：57.1 ）

ISSN： 1471-0056

年卷期： 2025 年 26 卷 5 期

页码：

收录情况： SCI

摘要： Synthetic genomics seeks to design and construct entire genomes to mechanistically dissect fundamental questions of genome function and to engineer organisms for diverse applications, including bioproduction of high-value chemicals and biologics, advanced cell therapies, and stress-tolerant crops. Recent progress has been fuelled by advancements in DNA synthesis, assembly, delivery and editing. Computational innovations, such as the use of artificial intelligence to provide prediction of function, also provide increasing capabilities to guide synthetic genome design and construction. However, translating synthetic genome-scale projects from idea to implementation remains highly complex. Here, we aim to streamline this implementation process by comprehensively reviewing the strategies for design, construction, delivery, debugging and tailoring of synthetic genomes as well as their potential applications. In this Review, James et al. provide an overview of approaches for planning, constructing, and fine-tuning synthetic genomes and describe their potential applications.

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