Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse

文献类型： 外文期刊

第一作者： Wu, Jianghong

作者： Wu, Jianghong;Gong, Husile;Zhang, Wenguang;Wu, Jianghong;Gong, Husile;Wu, Jianghong;Wu, Jianghong;Wu, Jianghong;Bai, Yongsheng;Bai, Yongsheng

作者机构：

期刊名称：BIOMED RESEARCH INTERNATIONAL （ 影响因子：3.411； 五年影响因子：3.62 ）

ISSN： 2314-6133

年卷期： 2016 年

页码：

收录情况： SCI

摘要： Genetic networks provide new mechanistic insights into the diversity of species morphology. In this study, we have integrated the MGI, GEO, and miRNA database to analyze the genetic regulatory networks under morphology difference of integument of humans and mice. We found that the gene expression network in the skin is highly divergent between human and mouse. The GO term of secretion was highly enriched, and this category was specific in human compared to mouse. These secretion genes might be involved in eccrine system evolution in human. In addition, total 62,637 miRNA binding target sites were predicted in human integument genes (IGs), while 26,280 miRNA binding target sites were predicted in mouse IGs. The interactions between miRNAs and IGs in human aremore complex than those inmouse. Furthermore, hsa-miR-548, mmu-miR-466, andmmu-miR-467 have an enormous number of targets on IGs, which both have the role of inhibition of host immunity response. The pattern of distribution on the chromosome of these three miRNAs families is very different. The interaction of miRNA/IGs has added the new dimension in traditional gene regulation networks of skin. Our results are generating new insights into the gene networks basis of skin difference between human and mouse.

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