Single Base-Resolution Methylome of the Dizygotic Sheep

文献类型： 外文期刊

第一作者： Wang, Yangzi

作者： Wang, Yangzi;Wu, Jianghong;Liu, Bin;Su, Rui;Jiang, Yu;Wang, Wen;Dong, Yang;Wu, Jianghong;Liu, Bin;Wu, Jianghong;Ma, Xiao;Su, Rui;Jiang, Yu

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2015 年 10 卷 11 期

页码：

收录情况： SCI

摘要： Sheep is an important livestock in the world for meat, dairy and wool production. The third version of sheep reference genome has been recently assembled, but sheep DNA methylome has not been profiled yet. In this study, we report the comprehensive sheep methylome with 94.38% cytosine coverage at single base resolution by sequencing DNA samples from Longissimus dorsi of dizygotic Sunit sheep, which were bred in different habitats. We also compared methylomes between the twin sheep. DNA methylation status at genome-scale differentially methylated regions (DMRs), functional genomic regions and 248 DMR-containing genes were identified between the twin sheep. Gene ontology (GO) and KEGG annotations of these genes were performed to discover computationally predicted function. Lipid metabolism, sexual maturity and tumor-associated categories were observed to significantly enrich DMR-containing genes. These findings could be used to illustrate the relationship between phenotypic variations and gene methylation patterns.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序