Epigenomic features associated with body temperature stabilize tissues during cold exposure in cold-resistant pigs

文献类型： 外文期刊

第一作者： Guo, Yaping

作者： Guo, Yaping;Hu, Mingyang;Peng, Hao;Zhang, Yan;Kuang, Renzhuo;Han, Zheyu;Wang, Daoyuan;Liao, Yinlong;Ma, Ruixian;Xu, Zhixiang;Sun, Jiahao;Shen, Yu;Zhao, Changzhi;Zhao, Shuhong;Zhao, Yunxia;Guo, Yaping;Hu, Mingyang;Peng, Hao;Zhang, Yan;Kuang, Renzhuo;Han, Zheyu;Wang, Daoyuan;Liao, Yinlong;Ma, Ruixian;Xu, Zhixiang;Sun, Jiahao;Shen, Yu;Zhao, Changzhi;Zhao, Shuhong;Zhao, Yunxia;Hu, Mingyang;Liao, Yinlong;Zhao, Changzhi;Zhao, Shuhong;Zhao, Yunxia;Ma, Hong;Liu, Di;Zhao, Shuhong

作者机构：

关键词： Cold exposure; Diencephalon tissue; Fat tissue; Breed difference; Multi-omics

期刊名称：JOURNAL OF GENETICS AND GENOMICS （ 影响因子：7.1； 五年影响因子：6.4 ）

ISSN： 1673-8527

年卷期： 2024 年 51 卷 11 期

页码：

收录情况： SCI

摘要： Cold stress in low-temperature environments can trigger changes in gene expression, but epigenomics regulation of temperature stability in vital tissues, including the fat and diencephalon, is still unclear. Here, we explore the cold-induced changes in epigenomic features in the diencephalon and fat tissues of two cold-resistant Chinese pig breeds, Min and Enshi black (ES) pigs, utilizing H3K27ac CUT&Tag, RNA-seq, and selective signature analysis. Our results show significant alterations in H3K27ac modifications in the diencephalon of Min pigs and the fat of ES pigs after cold exposure. Dramatic changes in H3K27ac modifications in the diencephalon of Min pig are primarily associated with genes involved in energy metabolism and hormone regulation, whereas those in the fat of ES pig are primarily associated with immunity-related genes. Moreover, transcription factors PRDM1 and HSF1, which show evidence of selection, are enriched in genomic regions presenting cold-responsive alterations in H3K27ac modification in the Min pig diencephalon and ES pig fat, respectively. Our results indicate the diversity of epigenomic response mechanisms to cold exposure between Min and ES pigs, providing unique epigenetic resources for studies of low-temperature adaptation in large mammals. Copyright (c) 2024, The Authors. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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