Anti-neuroinflammatory constituents from the fungus Penicillium purpurogenum MHZ 111

文献类型： 外文期刊

第一作者： Sun, Jing

作者： Sun, Jing;Zhu, Zhi-Xiang;Song, Yue-Lin;Ren, Yi;Zheng, Jiao;Zhao, Yun-Fang;Tu, Peng-Fei;Li, Jun;Sun, Jing;Ren, Yi;Dong, Dan;Liu, Ting

作者机构：

关键词： Penicillium purpurogenum;dihydroisocoumarin;coumarin;anti-neuroinflammatory activity

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）

ISSN： 1478-6419

年卷期： 2017 年 31 卷 5 期

页码：

收录情况： SCI

摘要： A new dihydroisocoumarin (1) and a new coumarin (2), along with eight known metabolites (3-10), were isolated from the solid substrate fermentation cultures of the fungus Penicillium purpurogenum MHZ 111. Their structures were elucidated by extensive spectroscopic analysis and comparison of their spectroscopic and physicochemical data with the literature values. Compounds 2 and 8 showed inhibition of nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells with IC50 values of 26.5 and 52.7 mu M, respectively.

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