The genetic regulatory network centered on Pto-Wuschela and its targets involved in wood formation revealed by association studies

文献类型： 外文期刊

第一作者： Yang, Xiaohui

作者： Yang, Xiaohui;Du, Qingzhang;Chen, Jinhui;Wang, Qingshi;Quan, Mingyang;Song, Yuepeng;Xie, Jianbo;Zhang, Deqiang;Yang, Xiaohui;Du, Qingzhang;Chen, Jinhui;Wang, Qingshi;Quan, Mingyang;Song, Yuepeng;Xie, Jianbo;Zhang, Deqiang;Wei, Zunzheng

作者机构：

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2015 年 5 卷

页码：

收录情况： SCI

摘要： Transcription factors (TFs) regulate gene expression and can strongly affect phenotypes. However, few studies have examined TF variants and TF interactions with their targets in plants. Here, we used genetic association in 435 unrelated individuals of Populus tomentosa to explore the variants in Pto-Wuschela and its targets to decipher the genetic regulatory network of Pto-Wuschela. Our bioinformatics and co-expression analysis identified 53 genes with the motif TCACGTGA as putative targets of Pto-Wuschela. Single-marker association analysis showed that Pto-Wuschela was associated with wood properties, which is in agreement with the observation that it has higher expression in stem vascular tissues in Populus. Also, SNPs in the 53 targets were associated with growth or wood properties under additive or dominance effects, suggesting these genes and Pto-Wuschela may act in the same genetic pathways that affect variation in these quantitative traits. Epistasis analysis indicated that 75.5% of these genes directly or indirectly interacted Pto-Wuschela, revealing the coordinated genetic regulatory network formed by Pto-Wuschela and its targets. Thus, our study provides an alternative method for dissection of the interactions between a TF and its targets, which will strength our understanding of the regulatory roles of TFs in complex traits in plants.

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