Role of AMPK mediated pathways in autophagy and aging

文献类型： 外文期刊

第一作者： Ge, Yuchen

作者： Ge, Yuchen;Zhou, Min;Chen, Cui;Wang, Xiaobo;Wang, Xiaobo;Wu, Xiaojian

作者机构：

关键词： AMPK; Autophagy; Aging; Signaling pathways; Disease

期刊名称：BIOCHIMIE （ 影响因子：3.9； 五年影响因子：3.9 ）

ISSN： 0300-9084

年卷期： 2022 年 195 卷

页码：

收录情况： SCI

摘要： AMPK is an important kinase regulating energy homeostasis and also a key protein involved in a variety of signal transduction pathways. It plays a vitally regulatory role in cellular senescence. Activation of AMPK can delay or block the aging process, which is of great significance in the treatment of cardiovascular diseases and other aging related diseases, and provides a potential target for new indications such as Alzheimer's disease. Therefore, AMPK signaling pathway plays an important role in aging research. The in-depth study of AMPK activators will provide more new directions for the treatment of age-related maladies and the development of innovative drugs. Autophagy is a process that engulfs and degrades own cytoplasm or organelles. Thereby, meeting the metabolic demands and updating certain organelles of the cell has become a hotspot in the field of anti-aging in recent years. AMPK plays an important role between autophagy and senescence. In our review, the relationship among AMPK signaling, autophagy and aging will be clarified through the interaction between AMPK and mTOR, ULK1, FOXO, p53, SIRT1, and NF -kappa B. (c) 2021 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.

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