Study of Synthesis and Biological Activities of a Novel Macrolide Derivatives
文献类型: 外文期刊
第一作者: Shi Daxin
作者: Shi Daxin;Feng Xue;Zhuang Xiaolei;Chai Hongxin;Zhang Qi;Li Jiarong;Liu Ting
作者机构:
关键词: macrolide;acylate;insecticidal activity;fungicidal activity
期刊名称:CHINESE JOURNAL OF ORGANIC CHEMISTRY ( 影响因子:1.652; 五年影响因子:1.2 )
ISSN: 0253-2786
年卷期: 2014 年 34 卷 12 期
页码:
收录情况: SCI
摘要: Modification of molecular structure of pesticides is a common method to seek new efficient broad-spectrum insecticides. This study focused on modifying the structure of deglycosylated or partially deglycosylated spinosad. Eight new macrolide derivatives had been synthesized by acylation. Their structures were characterized by H-1 NMR, C-13 NMR and MS techniques. Their fungicidal and insecticidal activities were also evaluated. The results showed that all compounds synthesized had excellent insecticidal activities against lepidoptera, coleoptera, diptera, hemiptera and nematoda. Compound 3e at the concentration of 100 mg/L presented 100% insecticidal activity against hemiptera (e.g. Myzus persicae) and compounds 3f and 3h loading 200 mu g presented certain inhibition against pseudomonas.
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