Inhibiting Effect of Bioactive Metabolites Produced by Mushroom Cultivation on Bacterial Quorum Sensing-Regulated Behaviors

文献类型： 外文期刊

第一作者： Zhu, Hu

作者： Zhu, Hu;Zhu, Hu;Zhang, Shuai-shuai;Cao, Chun-xu;Wang, Shou-xian

作者机构：

关键词： Bioactive metabolites;Chromobacterium violaceum CV026;Mushroom;N-Hexanoyl-L-homoserine lactone;Anti-quorum sensing;Violacein

期刊名称：CHEMOTHERAPY （ 影响因子：2.544； 五年影响因子：2.065 ）

ISSN： 0009-3157

年卷期： 2011 年 57 卷 4 期

页码：

收录情况： SCI

摘要： Aims: This study aimed to search for novel quorum sensing (QS) inhibitors from mushroom and to analyze their inhibitory activity, with a view to their possible use in controlling detrimental infections. Methods: The bioactive metabolites produced by mushroom cultivation were tested for their abilities to inhibit QS-regulated behavior. All mushroom strains were cultivated in potato-dextrose medium by large-scale submerged fermentation. The culture supernatant was condensed into 0.2 vol by freeze-drying. The condensed supernatant was sterilized by filtration through a 0.22-mu m membrane filter and added to Chromobacterium violaceum CV026 cultures, which were used to monitor QS inhibition. Inhibitory activity was measured by quantifying violacein production using a microplate reader. Results: The results have revealed that, of 102 mushroom strains, the bioactive metabolites produced by 14 basidiomycetes were found to inhibit violacein production, a QS-regulated behavior in C. violaceum. Conclusions: Higher fungi can produce QS-inhibitory compounds. Copyright (C) 2011 S. Karger AG, Basel

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