New Views on Strand Asymmetry in Insect Mitochondrial Genomes

文献类型： 外文期刊

第一作者： Wei, Shu-Jun

作者： Wei, Shu-Jun;Shi, Min;Chen, Xue-Xin;Ye, Gong-Yin;He, Jun-Hua;Wei, Shu-Jun;Shi, Min;Chen, Xue-Xin;Ye, Gong-Yin;He, Jun-Hua;Wei, Shu-Jun;Sharkey, Michael J.;van Achterberg, Cornelis

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2010 年 5 卷 9 期

页码：

收录情况： SCI

摘要： Strand asymmetry in nucleotide composition is a remarkable feature of animal mitochondrial genomes. Understanding the mutation processes that shape strand asymmetry is essential for comprehensive knowledge of genome evolution, demographical population history and accurate phylogenetic inference. Previous studies found that the relative contributions of different substitution types to strand asymmetry are associated with replication alone or both replication and transcription. However, the relative contributions of replication and transcription to strand asymmetry remain unclear. Here we conducted a broad survey of strand asymmetry across 120 insect mitochondrial genomes, with special reference to the correlation between the signs of skew values and replication orientation/gene direction. The results show that the sign of GC skew on entire mitochondrial genomes is reversed in all species of three distantly related families of insects, Philopteridae (Phthiraptera), Aleyrodidae (Hemiptera) and Braconidae (Hymenoptera); the replication-related elements in the A+T-rich regions of these species are inverted, confirming that reversal of strand asymmetry (GC skew) was caused by inversion of replication origin; and finally, the sign of GC skew value is associated with replication orientation but not with gene direction, while that of AT skew value varies with gene direction, replication and codon positions used in analyses. These findings show that deaminations during replication and other mutations contribute more than selection on amino acid sequences to strand compositions of G and C, and that the replication process has a stronger affect on A and T content than does transcription. Our results may contribute to genome-wide studies of replication and transcription mechanisms.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序