Luteinizing hormone receptor splicing variants in bovine Leydig cells

文献类型： 外文期刊

第一作者： Ma, T. H.

作者： Ma, T. H.;Xiong, Q. H.;Yuan, B.;Jiang, H.;Gao, Y.;Xu, J. B.;Liu, S. Y.;Zhang, J. B.;Yuan, B.;Gao, Y.;Ding, Y.;Zhang, J. B.;Zhang, G. L.;Zhao, Y. M.

作者机构：

关键词： Bovine;Leydig cells;LHR;Splicing variants

期刊名称：GENETICS AND MOLECULAR RESEARCH （ 影响因子：0.764； 五年影响因子：0.912 ）

ISSN： 1676-5680

年卷期： 2012 年 11 卷 2 期

页码：

收录情况： SCI

摘要： The luteinizing hormone receptor (LHR) plays a key role in testosterone production through its interaction with the gonadotropins, LH and chorionic gonadotropin. We examined the LHR splicing pattern in bovine Leydig cells; LH-induced expression of eight cloned splicing variants was detected by real-time PCR. Luteinizing hormone applied to cultured Leydig cells resulted in expression of full-length LHR and the A and B isoforms, as well as secretion of testosterone, which first increased, then declined, and then increased further, with increased LH levels. The secretion of testosterone progressively increased with increasing LH, but the expression levels of LHR (FL, A, and B) did not increase correspondingly. We conclude that the LHR splicing pattern is complex in bovine Leydig cells, and that expression of full-length LHR and isoforms A and B changes when induced with LH.

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